The Endocannabinoid System and You

The Endocannabinoid System and You


You're pretty much hardwired for it!


How Does Cannabidiol Interact With The Body?

All of the 60-plus cannabinoids unique to the plant genus Cannabis interact with our bodies thanks to a network of neurons called the endocannabinoid system.The endocannabinoid system runs throughout your body and it’s loaded with receptors that bind to the cannabinoids you introduce to your bloodstream when you consume cannabis. It’s the chemical interactions of those bonds that create a wide and largely unknown series of responses in your body.

Without distorting the science too much, you could say that human beings are “hard-wired” for cannabis. And even though cannabidiol has no toxicity for humans—meaning, it doesn’t make you intoxicated (i.e. high)—it is highly reactive with the endocannabinoid system.

To put things as simply as possible, CBD makes things happen. When it binds to the endocannabinoid system’s receptors, it stimulates all kinds of changes in the body

Most of those changes are incredibly beneficial, and researchers keep uncovering real and potential medical uses for them.

All humans – as well as other vertebrate creatures – are naturally equipped to respond to cannabinoids, the active compounds in cannabis. In fact, the human body manufactures cannabinoids all on its own. These naturally occurring cannabinoids and the ones found in cannabis activate the vast network of cannabinoid receptors found throughout the body – a network called the endocannabinoid system.

What Is the Endocannabinoid System?

Scientists first advanced the idea of a whole-body network of cannabis-sensitive receptors in the early 1990s, while studying the effects of marijuana. That led to the cloning of the first known cannabinoid receptor, CB1. Not long after, a second receptor, CB2, was identified, and in the following decades, research revealed that this system of receptors could be linked to nearly every function in the body, able to affect processes as diverse as immune responses, gut health, and mood.

The Endocannabinoid System Maintains Balance

Research on the scope and functioning of the endocannabinoid system reveals that its far-reaching network of receptors may be the “driver” of overall health, keeping the body’s many subsystems working in balance and supporting the immune responses that fight inflammation and other causes of disease.

To make that happen, both naturally occurring cannabinoids, THC and cannabidiol, or CBD, that come from cannabis are able to trigger the CB1 and CB2 receptors to stimulate neurotransmitter activity in the brain, central and peripheral nervous systems, and other essential regulatory systems throughout the body.

Endocannabinoid Deficiency May Cause Disease

Though the body may produce many others, at this point only two endocannabinoids have been well studied: anandamide and 2-arachidonoylglycerol, or 2-AG. The body normally produces enough of these compounds to maintain stability among its many systems, but studies suggest that low levels of endocannabinoids can lead to a condition called clinical endocannabinoid deficiency, which may account for conditions such as fibromyalgia, migraine, and irritable bowel syndrome.

It is possible to increase the production of endocannabinoids with exercise or even by eating certain foods such as turmeric, cumin, and pepper. But because the exogenous cannabinoids found in cannabis so perfectly match our native ones, many people turn to cannabis products containing CBD to ease chronic pain, anxiety and a number of conditions such as post-traumatic stress disorder, arthritis, and seizures.

The endocannabinoid system is a recent discovery, and research continues to add new insights into the many ways in which it supports health and mind-body balance. But workings of this complex system provide new evidence that, for many conditions, cannabis can be the natural way to wellness.