CBD And Drug Interactions: What Medication Should Not Be Taken With CBD?

CBD And Drug Interactions: What Medication Should Not Be Taken With CBD?

CBD products could help with a large variety of symptoms and are the go-to alternative treatment option for people looking to avoid side effects. But even though CBD has few side effects on its own, it could negatively interact with other medications you are taking. 

The Potential Magic of CBD

There are many CBD products available for purchase. You can buy CBD infused coffee, edibles, lotions, beverages, tinctures, and vapes. There is even a range of pet-friendly CBD products that are perfect for your furry best friend. So how does this hemp of marijuana extracted cannabinoid work?

CBD works by interacting with the body’s Endocannabinoid System (ECS). The ECS is responsible for keeping the body’s various systems functioning at their highest capacity. ECS maintains balance and homeostasis in your body as you encounter interferences from the outside world. 

By interacting with the ECS, CBD could affect blood pressure, immune response, and serotonin uptake. This is why it is essential that you know if any of the medications you are taking can negatively interact with CBD. 

CBD Drug Interactions

Metabolism and CYP System

When you take a CBD edible, beverage, or capsule - the CBD must go through your digestive system first and then get absorbed by the bloodstream. In the digestive tract, CBD is metabolized by a set of enzymes. 

A specific system in the liver is responsible for metabolizing drugs and other substances. This system is called Cytochrome P450 System (CYP), and it houses several specific enzymes that metabolize and help the absorption of ingested substances. So when you take a medication, it is digested by these special enzymes in your liver. 

The same enzymes digest CBD, so if you take a large amount of CBD and a prescribed medication, a significant amount of the enzymes would be spent on digesting the CBD. This could leave a less than desirable amount of enzymes to digest the medication. And that, in turn, could affect how well the medication works. 

Specific Medications

Medications that are digested in the liver and could be negatively impacted by CBD fall into the following categories

Antidepressants like Prozac, sertraline, and escitalopram are metabolized in the liver. The insufficient amount of enzymes left after CBD digestion can lead to a smaller amount of antidepressant medication being absorbed by the body. This can prevent the medicine from achieving the desired therapeutic effect. 

Antibiotics like amoxicillin, ciprofloxacin, and doxycycline could be affected by large doses of CBD. Overwhelming the liver enzymes with CBD metabolizing could result in an insufficient amount of the antibiotics being absorbed by the body. 

Beta-blockers and medications with a tranquilizing effect like Xanax could be less effective when taken with large amounts of CBD. Although CBD also has potential calming properties, it could minimize the prescription drug’s calming effects. 

CBD could also affect the absorption of steroids, anesthetics, antihistamines, and certain antiviral medications. So if you are taking prescription medications, it is always best to consult your physician before trying CBD!